requiring assistance of another party). Upward dose adjustments were allowed as clinically indicated, but were recommended to remain within 25% of the baseline insulin dose.All adverse events were recorded and assessed by the investigator as to severity and possible relationship to study medication. You can find out more about me and how to get in contact via my website Two patients of Teneligliptin group reported mild QT prolongation with Teneligliptin after 6 month of treatment.Type 2 Diabetes Mellitus is a progressive disease characterized by insulin resistance, impaired insulin secretion, increased glycogen dysplasia and obesity, the incidence of which has been rising consistently worldwide. Moreover multiple trails [6-9] on DPP-4 inhibitors have shown better glycemic control in type 2 diabetes mellitus patients and these patients had minimal risk of hypoglycemia and weight gain.Hydroxychloroquine inhibits insulin degradation and improve insulin sensitivity. Although it is impossible to tell what will happen with this study during peer review, the scientists involved are all very experienced with thousands of accepted scientific publications between them, so that their work would be inherently flawed with little-to-no merit at all is rather unlikely.“The results are neat and demonstrated the toxicity of this drug combination,” said Gaetan Burgio, MD, PhD, an infectious diseases expert from the Australian National University who has done several pre-clinical drug trials in mice. However, the authors of the new study stress that more work to look at this potential drug interaction in humans must be done as soon as possible.“Right now, the drugs are being used in a completely patchwork way. "Our study identified a signal for the association hydroxychloroquine + metformin that appears to be more at risk of fatal outcomes (particularly by completed suicides) than one of the two drugs when given alone," concluded the authors. The mean Post Prandial blood glucose level at week 24 decreased by 57.68±25.61 mg/dL in Hydroxychloroquine group and 43.1±22.38 mg/dL in Teneligliptin group.There is marginal change of BMI in Hydroxychloroquine group as compare to Teneligliptin group but differences in between the groups are not statistically significant.The change in lipid parameter levels (total cholesterol, LDL-C, HDL-C, non-HDL-C, triglycerides) from baseline to week 24 by group, as well as the differences between groups is shown in table 2. For the Hydroxychloroquine group, 53% of the subjects were male, the mean age was 55 ± 8 yr, and duration of diabetes was 9 ± 3 yr. For Teneligliptin group, 53% of subjects were male, the mean age was 56 ± 9 yr and duration of diabetes was 10 ± 2 yr.

Even there was statistically significant reduction in FBG and PBG in Hydroxychloroquine group as compare to Teneligliptin group (p<0.001).Hypoglycaemia is a major limiting barrier to good glycaemic control with insulin [19]. Patient with known history of diabetic ketoacidosis, Glucose-6-phophodehydrogenase deficiency, existing diabetic retinopathy of any grade including diabetic retinopathy requiring laser therapy, evidence of an imminent need for retinal laser therapy, uncorrected visual acuity <20/100, abnormal visual fields, difficulty to examine optic disc or evidence of retinal pigment epithelial abnormalities and patients with history or risk of macular edema.Of the 356 subjects screened for this study, 320 subjects were randomized to either the Hydroxychloroquine or teneligliptin group. Although insulin dose adjustments were allowed during the study, patients were asked to use the same type of insulin throughout, and if possible to maintain their daily insulin regimen. Patients were randomly divided into two groups one received Teneligliptin 20 mg (n=152) and other received Hydroxychloroquine 400 mg (n=148) while continuing insulin therapy with other two OHA.

Testing drugs on mice is an important step in the approval of all new treatments to go into human clinical trials and promising drugs which cause severe toxicities in mice, generally don’t make it into human trials. They were asked to record the measured values at any time hypoglycaemia was suspected and also prior to breakfast at least three times per day. There seems to be no mention of any possible mechanism or reason as to why these two drugs killed the mice.

This could change in weeks or months from now, as the results of new trials come out. Hydroxychloroquine is an immunomodulatory drug that has been used for the treatment of malaria and autoimmune diseases. [11], which showed further 30% reduction of insulin dose with addition of Hydroxychloroquine 400 mg. Change in Insulin dosage and time of insulin injection among Teneligliptin dose was also noticed but compare to Hydroxychloroquine group it was much lesser. It was ensure that all patients under this study uses the same type of device with a view to performing routine self-monitored blood glucose (SMBG) measurements as instructed by the investigator.

Severe hypoglycaemia was defined as any episode requiring the assistance of another party (with plasma glucose value <70 mg/dl, unless the severity of the event precluded glucose determination).All statistical analyses were performed using statistical software (Graph Pad Prism, version 6).

However, some drugs Secondly, the study has not yet been peer-reviewed by other scientists to check its credibility, nor accepted for publication in a scientific journal.