Following a single intravenous dose, systemic clearance of metronidazole was decreased by 66% in patients compared with healthy controls (p < 0.001). To make sure the tablets, liquid or suppositories are safe for you, tell your doctor if you: have had an allergic reaction to metronidazole or any other medicines in the past; are pregnant or breastfeeding; have liver problems; are having dialysis

The colitis is usually characterized by severe, persistent diarrhea and severe abdominal cramps, and may be associated with the passage of blood and mucus.
even though they kept saying they had no idea what was wrong and kept sending me home.

A pharmacokinetic study of metronidazole disposition was performed in 10 patients with severe liver disease, the majority of whom also had impaired renal function.

Symptoms may include nausea, vomiting, flushing, sweating, headache, abdominal cramps, and hypotension. Antibiotic therapy can alter the normal flora of the colon and permit overgrowth of Clostridium difficile, whose toxin is believed to be a primary cause of antibiotic- associated colitis.


Applies to: hemodialysisMetronidazole and its metabolites are moderately removed by hemodialysis. Therapy with metronidazole should be administered cautiously at reduced dosages in patients with severe liver disease. RTU (brand of metronidazole ready-to-use injection) contains 14 mEq of sodium per each 500 mg dose of metronidazole.

and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username Metronidazole isn't suitable for some people. Stool cultures for Clostridium difficile and stool assay for C. difficile toxin may be helpful diagnostically. Applies to: History - Blood Dyscrasias, Bone Marrow Depression/Low Blood CountsThe use of nitroimidazoles (e.g., metronidazole, tinidazole) has rarely been associated with hematologic adverse effects such as mild, transient leukopenia, thrombocytopenia, and bone marrow aplasia.

Department of Medicine and the Paediatric Pharmacology Unit, Westmead, N.S.W. Purpose .

Therapy with nitroimidazoles should be administered cautiously in patients who might be prone to acute alcohol intake. Applies to: AlcoholismNitroimidazoles (e.g., metronidazole, tinidazole) may inhibit alcohol dehydrogenase and occasionally precipitate a disulfiram-like reaction in patients who consume alcohol while being treated.

An alternative therapy may be appropriate.Moderate Potential Hazard, High plausibility. A large bowel endoscopy may be considered to establish a definitive diagnosis in cases of severe diarrhea.Major Potential Hazard, Low plausibility.

A pharmacokinetic study of metronidazole disposition was performed in 10 patients with severe liver disease, the majority of whom also had impaired renal function. 2145, AustraliaDepartment of Medicine and the Paediatric Pharmacology Unit, Westmead, N.S.W. Following a single intravenous dose, systemic clearance of metronidazole was decreased by 66% in patients compared with healthy controls (p …

Drug induced liver injury (DILI) can result either from dose-dependent direct hepatotoxicity or from an unpredictable dose-independent idiosyncratic reaction.