Indeed, over Two more conclusions to derive from all this: first, suggesting that primary care colleagues do not use adequate doses of antidepressants is not warranted. In the treatment of depression, primary care providers are often faulted for failing to give an antidepressant medication at a high enough dose. For example, from compilations of fixed-dose randomized trials, psychopharmacologist Sheldon Preskorn[[{"type":"media","view_mode":"media_crop","fid":"38936","attributes":{"alt":"antidepressants","class":"media-image media-image-right","height":"122","id":"media_crop_7261940819378","media_crop_h":"0","media_crop_image_style":"-1","media_crop_instance":"4042","media_crop_rotate":"0","media_crop_scale_h":"0","media_crop_scale_w":"0","media_crop_w":"0","media_crop_x":"0","media_crop_y":"0","style":"float: right;","title":"©TheLen/Shutterstock.com","typeof":"foaf:Image","width":"188"}}]]Indeed, many practitioners would have increased the dose at Since pushing the dose of SNRIs can increase blood pressure as well, Dr Berney’s analysis raises some doubt about this common approach.

The ATC/DDD system has been developed as a tool for drug utilization research. He maintains his research interests and will take up a clinical lectureship post from February. We retrieved all randomized, double-blind, flexible-dose trials comparing fluoxetine or paroxetine with any other active antidepressants as monotherapy in the acute phase treatment of unipolar depression. Doses equivalent to 1mg olanzapine, 1mg risperidone, 1mg haloperidol, and 100mg chlorpromazine were presented and compared with the results of 3 other methods to define dose equivalence (the “minimum effective dose method,” the “classical mean dose method,” and an international consensus statement).We presented dose equivalents for 57 first-generation and second-generation antipsychotic drugs, available as oral, parenteral, or depot formulations. ScienceDirect ® is a registered trademark of Elsevier B.V.Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trialsCopyright © 2015 The Authors. For permissions, please email: journals.permissions@oup.com Sorry…Clinicians & service users looking to switch #antidepressants should read this new evidence on dose equivalents Researchers who compare various #antidepressants will be interested in this new evidence on dose equivalents Don’t miss: Dose equivalents of antidepressants – standardising prescribing between different drugs Mental Elf: Dose equivalents of antidepressants: standardising prescribing between different drugs “@Mental_Elf: Clinicians service users switching #antidepressants should read this new evidence on dose equivalents “@Mental_Elf new evidence on dose equivalents for antidepressants #Dose equivalents of #antidepressants: standardising #prescribing between different drugs “Dose equivalents of antidepressants: standardising prescribing between different drugs” Do you have a suggestion for a paper? It provides a standardisation between antidepressants and research studies. Welcome to eLQ, the equivalent dose calculator: Calculator. All rights reserved. Introduction. No misinformation. No spin. But they also point out that based on the data we have for SSRIs, “In other words, if the patient is not improving on a starting dose (eg, fluoxetine 10 mg, sertraline 50 mg, escitalopram 5 mg), doubling the dose in non-responders is reasonable. She examines each of the available studies Yet in an interesting logical twist on all this, Stanford's Drs Based on that logic, Solvason and DeBattista conclude that increasing dosages in patients who do not respond to an initial doseis not unreasonable. The most important limitation is that DDDs have not been developed for the purpose of dose equivalence. Definitely, one SSRI isn't equivalent to another in lots of ways. Published by Elsevier B.V.ScienceDirect ® is a registered trademark of Elsevier B.V. Equivalent dosing is important to guarantee fair comparisons of drugs, To explore whether DDDs can be an appropriate estimate of antipsychotic dose equivalence, we ( “The defined daily dose DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults.” As DDDs are the assumed average maintenance doses for drugs for their main indication, we extracted the DDDs of all drugs listed in the section “antipsychotic drugs” (ATC code N05A, Olanzapine Equivalents Based on DDDs, the Minimum Effective Dose Method, the Classical Mean Dose Method, and an International Consensus The first 2 columns present the DDDs for oral and parenteral/depot drugs according to the WHO ( Olanzapine Equivalents Based on DDDs, the Minimum Effective Dose Method, the Classical Mean Dose Method, and an International Consensus The first 2 columns present the DDDs for oral and parenteral/depot drugs according to the WHO ( DDDs are frequently used in research about antipsychotic drugs. There are many reasons why it is important to have dose equivalence estimates for antipsychotic drugs. For these situations we present an excel sheet on our home page ( In the last 3 years, Stefan Leucht has received honoraria for lectures from EliLilly, Lundbeck (Institute), Pfizer, Janssen, BMS, Johnson and Johnson, Otsuka, Roche, SanofiAventis, ICON, Abbvie, AOP Orphan, Servier; for consulting/advisory boards from Roche, Janssen, Lundbeck, EliLilly, Otsuka, TEVA; for the preparation of educational material and publications from Lundbeck Institute and Roche.