The cosmetic mouthrinses are over-the-counter products that are mainly intended as mouth fresheners. 2003, 3: CD002284-Twetman S, Petersson L, Axelsson S, Dahlgren H, Holm AK, Kallestal C, Lagerlof F, Lingstrom P, Mejare I, Nordenram G, Norlund A, Soder B: Caries-preventive effect of sodium fluoride mouthrinses: a systematic review of controlled clinical trials. 2003, 82: 206-211.Reynolds EC, Cain CJ, Webber FL, Black CL, Riley PF, Johnson I, Perich JW: Anticariogenicity of calcium phosphate complexes of tryptic casein phosphopeptides in the rat. J Dent Res. Dentifrice products with strong taste characteristics may cause excessive salivary stimulation, which would increase the rate of fluoride clearance from the mouth.Concerns have been raised that agents that inhibit calculus formation, such as pyrophosphate, may also interfere with the remineralization process. Document page views are updated periodically throughout the day and are cumulative counts for this document including its time on Public Inspection. The testing procedures for these biological tests are labeled Biological Testing Procedures for Fluoride Dentifrices; these testing procedures are on file under Docket No. 1993, S55-58. 1972, 38: 213-218.DePaola PF, Soparkar PM, Triol C, Volpe AR, Garcia L, Duffy J, Vaughan B: The relative anticaries effectiveness of sodium monofluorophosphate and sodium fluoride as contained in currently available dentifrice formulations.

the Federal Register. J. Dent.

There is a general understanding that the fluoride compound, concentration, frequency of use, duration of exposure, and method of delivery can influence fluoride efficacy. (a) A fluoride dentifrice drug product shall meet the biological test requirements for animal caries reduction and one of the following tests: Enamel solubility reduction or fluoride enamel uptake. Documents 1991, 25: 330-334.van der Hoeven JS, Schaeken MJ, Creugers TJ: Effect of a mouthrinse containing calcium lactate on the formation and mineralization of dental plaque. documents in the last year


Biological Testing Procedures for Fluoride Dentifrices However, since that time, several citizen petitions (Refs. Clinical pilot study. Information about this document as published in the

Part of 1993, 27: 328-336.Proskin HM, Volpe AR: Comparison of the anticaries efficacy of dentifrices containing fluoride as sodium fluoride or sodium monofluorophosphate. 34 This table of contents is a navigational tool, processed from the documents in the last year 10.1111/j.1600-0528.1990.tb00661.x.Horowitz AM: A report on the NIH consensus development conference on diagnosis and management of dental caries throughout life. The testing procedures for these biological tests are labeled Biological Testing Procedures for Fluoride Dentifrices; these testing procedures are on file under Docket No. Caries Res. 1997, 24: 325-331. J Dent Educ. 77?83 [30] BS 5136:1981, Specification for toothpastes [31] ISO 16212, Cosmetics ? American Dental Association, 1989 [29] H attab, F.N. 194 1986, 5: 1-97.Kashket S: Historical review of remineralization research. 1988, 22: 362-370.Yamaga R, Nishino M, Yoshida S, Yokomizo I: Diammine silver fluoride and its clinical application. J Dent Res.

Trace amounts of fluoride in saliva are effective in shifting the balance from demineralization to remineralization. documents in the last year Any proposed modification or alternative testing procedures shall be submitted as a petition in accord with § 10.30 of this chapter. 80N-0042 in the Division of Dockets Management (HFA-305), Food and Drug Administration… J Dent Res. This method can evaluate the effect of treatment time and dilution on the ability of oral care products to promote fluoride uptake.

J Dent Res.

The monograph refers to the Biological Testing Procedures for Fluoride Dentifrices (Federal Register Docket No. 23

A dual action whitening technology based on sodium fluoride dentifrices evolved from these early efforts. A recent study has reported on the quality control of dentifrices from non-established market economy countries [The use of mouthrinses to deliver chemotherapeutic agents is well accepted by the public, both by self administration [Many types of mouthrinse active ingredients have been evaluated for their plaque- reducing effectiveness and ability to reduce mutans streptococci, including chlorhexidine, essential oils, triclosan, cetylpyridinium chloride, sanquinarin, sodium dodecyl sulphate, and various metal ions (tin, zinc, copper). J. Casein phosphopeptide (CPP) amorphous calcium-phosphate (ACP) complexes have been reported to increase the level of calcium phosphate in plaque [A number of calcium phosphate compounds have been evaluated by researchers at the ADA Health Foundation, Paffenbarger Research Center.