A twofold increase in the ciprofloxacin half‐life may be partly explained by a decrease in the glomerular filtration rate, as shown by slower ciprofloxacin renal clearance (152.4 ± 54.2 vs 395.6 ± 139.0 for elderly and young subjects respectively; p < 0.001).
2003;20(4):289-302. doi: 10.2165/00002512-200320040-00005.
[PMC free article] Guay DR, Awni WM, Peterson PK, Obaid S, Stein D, Breitenbucher R, Matzke GR.
COVID-19 is an emerging, rapidly evolving situation. Ciprofloxacin is an effective treatment for those infections most common in elderly patients, including infections of the urinary tract, lower respiratory tract, skin and soft-tissues, and bone and joints, and is an effective agent for prophylaxis in transurethral surgery.
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I have read and accept the Wiley Online Library Terms and Conditions of UseA pharmacokinetic-pharmacodynamic assessment of oral antibiotics for pyelonephritis, European Journal of Clinical Microbiology & Infectious Diseases, A Physiologically-Based Pharmacokinetic Model to Describe Ciprofloxacin Pharmacokinetics Over the Entire Span of Life, Inflammatory Bowel Disease: Pathophysiology and Current Therapeutic Approaches, Ciprofloxacin in Elderly Patients with Underlying Chronic Diseases, A Qualitative Review on the Pharmacokinetics of Antibiotics in Saliva: Implications on Clinical Pharmacokinetic Monitoring in Humans, When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. 2010 Mar 1;27(3):193-209. doi: 10.2165/11531490-000000000-00000.Drugs Aging.
Nevertheless, with its good tolerability profile and potent antimicrobial activity following oral administration, ciprofloxacin appears to offer a valuable alternative for treating various acute and chronic infections in elderly patients.
Cipro Side Effects In Women .
However, elderly patients are more likely to have age-related kidney or heart problems, or develop severe tendon problems (including tendon rupture), which may require caution in patients receiving ciprofloxacin.
1988 May-Jun;10(3):528-43. doi: 10.1093/clinids/10.3.528.Pisano S, Giustiniani M, Francis L, Gonzalez D, Margarit L, Sheldon IM, Paolino D, Fresta M, Conlan RS, Healey GD.Biomed Microdevices.
ZALOPHUS CALIFORNIANUS doi: 10.2165/00002512-199404020-00007. All rights reserved. Irritation Of The Stomach Or Intestines
Antimicrob Agents Chemother.
New Test Can Tell
It is effective after oral or intravenous administration, demonstrating potent antibacterial activity against most Gram-negative, and many Gram-positive bacteria. Ciprofloxacin pharmacokinetics in patients with normal and impaired renal function. Ciprofloxacin oral liquid or tablet may be used in children to prevent anthrax infection after possible exposure, and to treat serious kidney infections.
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Ciprofloxacin is not used as often as some other antibitotics because of the risk of serious side effects.
Orally administered ciprofloxacin appeared to be at least as effective as alternative orally administered antimicrobial agents (trimethoprim, cotrimoxazole [trimethoprim/sulfamethoxazole], amoxicillin, amoxicillin/clavulanic acid) and also as effective as various parenteral agents (ceftriaxone, cefamandole, ceftazidime, cefotaxime) in a small number of comparative clinical trials. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.The presence of other medical problems may affect the use of this medicine.