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Most of the hydrophilic derivatives of natural cyclodextrins like 2-hydroxypropyl-Considering the regulatory aspects of various cyclodextrins, it is still evolving. Eur J Pharm Biopharm. Badea I, Virtanen C, Verrall RE, Rosenberg A, Foldvari M. Effect of topical interferon-γ gene therapy using gemini nanoparticles on pathophysiological markers of cutaneous scleroderma in Tsk/ + mice. Song H-Q, Qi Y, Li R-Q, Cheng G, Zhao N, Xu F-J. Efficacy, safety, and durability of voretigene neparvovec-rzyl in RPE65 mutation–associated inherited retinal dystrophy: results of phase 1 and 3 trials. Beyond cystic fibrosis transmembrane conductance regulator therapy: a perspective on gene therapy and small molecule treatment for cystic fibrosis. J Control Release.

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Klein K, Mann JFS, Rogers P, Shattock RJ. This is an open access article distributed under the We are committed to sharing findings related to COVID-19 as quickly as possible. 42-706/2013 (SR) and CCOST/MRP/2012 Endt. Effects of cyclodextrin derivatives on bioavailability of ketoprofen.Dhanaraju MD, Santil Kumaran K, Baskaran T, Moorthy MSR. Free siRNA do not produce efficient and predictable therapeutic effect. Sci Rep. 2019;9:1–17.

The authors are also thankful to UGC-MRP F. no. 2018;9:2281–9. Polym Chem. The safety and toxicity of cyclodextrins depend on the route of administration.

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In an oral drug delivery system (DDS), the hydrophilic and ionizable CDs can serve as potent drug carriers in the immediate release- and delayed release-formulations, respectively, while the release rate of water-soluble drugs can be retarded by hydrophobic CDs. Use of beta-cyclodextrins to prevent modifications of the properties of carbopol hydrogels due to carbopol-drug interactions.Muñoz-Ruiz AM, Paronen P. Particle and powder properties of cyclodextrins.Zannou EA, Streng WH, Stella VJ. Cell Gene Ther Insights. This section highlights the contribution of those cyclodextrin-based therapeutic systems, which are under clinical trials or have been approved for human use [In past 5 years, the significant contributions of cyclodextrins and their derivatives in drug delivery are discussed here, Dabur Pharma, one of India’s leading manufacturers of anticancer drugs, launched Nanoxel, a novel drug delivery system for Paclitaxel, in 2007. Accessed May 25, 2005.CyDex Inc Web site. Effective melanoma immunotherapy with interleukin-2 delivered by a novel polymeric nanoparticle.

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Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways.

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Linear poly(ethylenimine) cross-linked by methyl-β-cyclodextrin for gene delivery. This ensures the longer residence of gel at the vagina, HPV-infection site, and the genital tract. Acta Biomater. While much of the initial success of gene delivery relied on viral vectors, non-viral vectors are emerging as promising gene delivery systems for efficacious treatment with decreased toxicity concerns.