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Most of the hydrophilic derivatives of natural cyclodextrins like 2-hydroxypropyl-Considering the regulatory aspects of various cyclodextrins, it is still evolving. Eur J Pharm Biopharm. Badea I, Virtanen C, Verrall RE, Rosenberg A, Foldvari M. Effect of topical interferon-γ gene therapy using gemini nanoparticles on pathophysiological markers of cutaneous scleroderma in Tsk/ + mice. Song H-Q, Qi Y, Li R-Q, Cheng G, Zhao N, Xu F-J. Efficacy, safety, and durability of voretigene neparvovec-rzyl in RPE65 mutation–associated inherited retinal dystrophy: results of phase 1 and 3 trials. Beyond cystic fibrosis transmembrane conductance regulator therapy: a perspective on gene therapy and small molecule treatment for cystic fibrosis. J Control Release.
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The authors are also thankful to UGC-MRP F. no. 2018;9:2281–9. Polym Chem. The safety and toxicity of cyclodextrins depend on the route of administration.
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In an oral drug delivery system (DDS), the hydrophilic and ionizable CDs can serve as potent drug carriers in the immediate release- and delayed release-formulations, respectively, while the release rate of water-soluble drugs can be retarded by hydrophobic CDs. Use of beta-cyclodextrins to prevent modifications of the properties of carbopol hydrogels due to carbopol-drug interactions.Muñoz-Ruiz AM, Paronen P. Particle and powder properties of cyclodextrins.Zannou EA, Streng WH, Stella VJ. Cell Gene Ther Insights. This section highlights the contribution of those cyclodextrin-based therapeutic systems, which are under clinical trials or have been approved for human use [In past 5 years, the significant contributions of cyclodextrins and their derivatives in drug delivery are discussed here, Dabur Pharma, one of India’s leading manufacturers of anticancer drugs, launched Nanoxel, a novel drug delivery system for Paclitaxel, in 2007. Accessed May 25, 2005.CyDex Inc Web site. Effective melanoma immunotherapy with interleukin-2 delivered by a novel polymeric nanoparticle.
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Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways.
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Linear poly(ethylenimine) cross-linked by methyl-β-cyclodextrin for gene delivery. This ensures the longer residence of gel at the vagina, HPV-infection site, and the genital tract. Acta Biomater. While much of the initial success of gene delivery relied on viral vectors, non-viral vectors are emerging as promising gene delivery systems for efficacious treatment with decreased toxicity concerns.