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Information about drug Fluconazole includes cost of the drug and the type of drug - … Tell your doctor right away if you get a rash while taking fluconazole.Fluconazole may cause other less common side effects besides those listed here. In post-marketing experience, spontaneous reports of anemia and acute renal failure were more frequent among patients 65 years of age or older than in those between 12 and 65 years of age. Co-administration of terfenadine is contraindicated in patients receiving fluconazole at multiple doses of 400 mg/day or higher based upon results of a multiple dose interaction study.
These rates were comparable to control products. Caution should be exercised when fluconazole is administered to a nursing woman.An open-label, randomized, controlled trial has shown fluconazole to be effective in the treatment of oropharyngeal candidiasis in children 6 months to 13 years of age (See The use of fluconazole in children with cryptococcal meningitis, In a noncomparative study of children with serious systemic fungal infections, most of which were candidemia, the effectiveness of fluconazole was similar to that reported for the treatment of candidemia in adults. [See USP Controlled Room Temperature.] If you develop any side effects that concern you, call your doctor.
Read this information carefully before you take fluconazole. Vaginal yeast infections are common.
The effects on parturition in rats are consistent with the species specific estrogen-lowering property produced by high doses of fluconazole.
About three out of every four adult women will have at least one vaginal yeast infection during their life.Some medicines and medical conditions can increase your chance of getting a yeast infection. Fluconazole is also used for other conditions. There is no need to adjust single dose therapy for vaginal candidiasis because of impaired renal function.
However, it may take several days for your symptoms to go away completely. Other side effects reported with an incidence equal to or greater than 1% included diarrhea (3%), dyspepsia (1%), dizziness (1%), and taste perversion (1%). Co-administration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as cisapride, astemizole, erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole (See Some azoles, including fluconazole, have been associated with prolongation of the QT interval on the electrocardiogram. After reconstitution with 24 mL of distilled water or Purified Water (USP), each mL of reconstituted suspension contains 10 mg or 40 mg of fluconazole USP.The reconstituted suspension meets the requirements of the Test 2 Dissolution in the USP monograph for Fluconazole for Oral Suspension, USP.The pharmacokinetic properties of fluconazole are similar following administration by the intravenous or oral routes. All doses are once daily. In patients with fungal meningitis, fluconazole concentrations in the cerebrospinal fluid (CSF) are approximately 80% of the corresponding plasma concentrations.A single oral 150 mg dose of fluconazole administered to 27 patients penetrated into vaginal tissue, resulting in tissue: plasma ratios ranging from 0.94 to 1.14 over the first 48 hours following dosing.A single oral 150 mg dose of fluconazole administered to 14 patients penetrated into vaginal fluid, resulting in fluid: plasma ratios ranging from 0.36 to 0.71 over the first 72 hours following dosing.In normal volunteers, fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. If you cannot reach your doctor, go to the nearest hospital emergency room. Patients who develop abnormal liver function tests during fluconazole therapy should be monitored for the development of more severe hepatic injury.
In both, the results of the fluconazole regimen were comparable to the control regimen (clotrimazole or miconazole intravaginally for 7 days) both clinically and statistically at the one month post-treatment evaluation.The therapeutic cure rate, defined as a complete resolution of signs and symptoms of vaginal candidiasis (clinical cure), along with a negative KOH examination and negative culture for Approximately three-fourths of the enrolled patients had acute vaginitis (<4 episodes/12 months) and achieved 80% clinical cure, 67% mycologic eradication, and 59% therapeutic cure when treated with a 150 mg fluconazole tablet administered orally.
Fluconazole is different from other treatments for vaginal yeast infections because it is a tablet taken by mouth.