Following intravenous administration, both amoxicillin and clavulanic acid have been found in the gall bladder, abdominal tissue, skin, fat, muscle tissues, synovial and peritoneal fluids, bile and pus.

Store in the original package.Sealing-strips of aluminium foil with a polyethylene coating on the inner side, or aluminium blisters with a PVC coating on the inner side, as single packs of 15 or 21 film-coated tablets and hospital packs of 100 film-coated tablets.Park View, Riverside Way, Watchmoor Park, Camberley, Surrey, GU15 3YL, UKTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. The medicine will come with a plastic syringe or spoon to help you measure out the right dose. Amoxi-Clav: This combination product containing amoxicillin and clavulanic acid belongs to the group of medications known as antibiotics. Trace quantities of clavulanic acid can also be detected in breast milk (see section 4.6).Both amoxicillin and clavulanic acid have been shown to cross the placental barrier (see section 4.6).Amoxicillin is partly excreted in the urine as the inactive penicilloic acid in quantities equivalent to up to 10 to 25% of the initial dose. Doses in renal impairment must therefore, prevent undue accumulation of amoxicillin while maintaining adequate levels of clavulanic acid (see section 4.2). Elderly. In patients with bladder catheters, a regular check of patency should be maintained (see section 4.9).During treatment with amoxicillin, enzymatic glucose oxidase methods should be used whenever testing for the presence of glucose in urine because false positive results may occur with non-enzymatic methods.The presence of clavulanic acid in Co-amoxiclav may cause a non-specific binding of IgG and albumin by red cell membranes leading to a false positive Coombs test.There have been reports of positive test results using the Bio-Rad Laboratories Platelia Oral anticoagulants and penicillin antibiotics have been widely used in practice without reports of interaction. For a full list see the leaflet inside your medicines packet.It's usually safe to take co-amoxiclav during pregnancy and while breastfeeding.For more information about how co-amoxiclav can affect you and your baby during pregnancy, For safety, tell your doctor if you're trying to get pregnant, are already pregnant or if you're breastfeeding.There are some medicines that do not mix well with co-amoxiclav. If an allergic reaction occurs, amoxicillin/clavulanic acid therapy must be discontinued and appropriate alternative therapy instituted. Some bacteria are able to produce a chemical which makes amoxicillin less effective. You can opt out at any time or find out more by reading our The prevalence of resistance may vary geographically and with time for selected species, and local information on resistance is desirable, particularly when treating severe infections. Amoxicillin crystalluria, in some cases leading to renal failure, has been observed (see section 4.4). If an allergic reaction occurs, amoxicillin/clavulanic acid therapy must be discontinued and appropriate alternative therapy instituted.In the case that an infection is proven to be due to an amoxicillin-susceptible organisms(s) then consideration should be given to switching from amoxicillin/clavulanic acid to amoxicillin in accordance with official guidance.This presentation of Co-amoxiclav is not suitable for use when there is a high risk that the presumptive pathogens have reduced susceptibility or resistance to beta-lactam agents that is not mediated by beta-lactamases susceptible to inhibition by clavulanic acid (Convulsions may occur in patients with impaired renal function or in those receiving high doses (see section 4.8).Amoxicillin/clavulanic acid should be avoided if infectious mononucleosis is suspected since the occurrence of a morbilliform rash has been associated with this condition following the use of amoxicillin.Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions.Prolonged use may occasionally result in overgrowth of non-susceptible organisms.

Patient does not provide medical advice, diagnosis or treatment.Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA.

£All methicillin-resistant staphylococci are resistant to Co-Amoxiclav.Amoxicillin and clavulanic acid, are fully dissociated in an aqueous solution at physiological pH. In the rest of this leaflet the medicine will be called Co-amoxiclav. Repeat dose toxicity studies performed in dogs with Co-Amoxiclav demonstrated gastric irritancy and vomiting, and discolouring of the tongue. In the case that an infection is proven to be due to an amoxicillin-susceptible organisms(s) then consideration should be given to switching from amoxicillin/clavulanic acid to amoxicillin in accordance with official guidance. Treatment should not be extended beyond 14 days without review. It allows continued monitoring of the benefit/risk balance of the medicinal product. 6. Co-amoxiclav 250 mg/125 mg film-coated tablets are not recommended in children < 40 kg. Dose with caution and monitor hepatic function at regular intervals (see sections 4.3 and 4.4). If you are having any vaccinations, make sure the person treating you knows that you are taking this antibiotic.