• Where peripheral vasoconstriction suggests low cardiac output, the use of Trandate Injection/Labetalol Injection to control hypertensive episodes following acute myocardial infarction is contra-indicated.There have been reports of skin rashes and/or dry eyes associated with the use of beta-adrenoceptor blocking drugs. BJOG 2012;119:78–85; Shekhar S, Sharma C, Thakur S, Verma S. Oral nifedipine or intravenous labetalol for hypertensive emergency in pregnancy: a randomized controlled trial. Name must be less than 100 characters BJOG 2012;119:78–85; Shekhar S, Sharma C, Thakur S, Verma S. Oral nifedipine or intravenous labetalol for hypertensive emergency in pregnancy: a randomized controlled trial. In one case, the use of dopamine to increase the blood pressure may have aggravated the renal failure.Labetalol does have membrane stabilising activity which may have clinical significance in overdosage.Haemodialysis removes less than 1% labetalol hydrochloride from the circulation.Labetalol lowers the blood pressure primarily by blocking peripheral arteriolar alpha-adrenoceptors thus reducing peripheral resistance and, by Concurrent beta-blockade protects the heart from reflex sympathetic drive that would otherwise occur. Oral nifedipine versus intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnancy: a randomised trial. • Uncontrolled, incipient or digitalis refractory heart failure. Enroute to the operating theatre, the patient had an eclamptic seizure. Labetalol crosses the placental barrier and the possibility of the consequences of alpha- and beta-adrenoceptor blockade in the foetus and neonate should be borne in mind. No adverse effects were encountered, but one subject had a transitory hypotensive episode that did not require treatment. Most hypertensive emergencies occur in patients with known hypertension and are the result of inadequate treatment or poor compliance [1]. Clipboard, Search History, and several other advanced features are temporarily unavailable. Cardiac output is not significantly reduced at rest or after moderate exercise. doi: 10.1097/00005344-198100031-00007. When clonidine is used in conjunction with non-selective beta-blockers, such as propranolol, treatment with clonidine should be continued for some time after treatment with the beta-blocker has been discontinued. Intravenous labetalol appears effective and well tolerated in the control of blood pressure in hypertensive emergencies.Please check your email for instructions on resetting your password. Lebel M, Langois S, Belleau LJ, Grose JH.

Bradycardia or extensive vagal reactions should be treated by administering atropine or methylatropine. This site needs JavaScript to work properly. It should be administered using a paediatric giving set fitted with a 50ml graduated burette to facilitate dosage.It is desirable to monitor the heart rate after injection and during infusion. Such patients may be unresponsive to the usual doses of epinephrine use to treat allergic reaction.The label will state “Do not take Trandate Injection/Labetalol Injection if you have a history of wheezing or asthma as it can make your breathing worse.” View Show abstract Discussion. intravenous fluids and glucose) is usually prompt but with severe pre-eclampsia, particularly after prolonged intravenous labetalol, recovery may be slower. By the end of the infusion, diastolic blood pressure in 16 (73%) subjects was lowered to ≤110 mm Hg. Labetalol in hypertensive emergencies. over 1-2 weeks, if necessary at the same time initiating replacement therapy, to prevent exacerbation of angina pectoris. Intravenous infusion. Labetalol lasts ~2-4 hours, so it doesn't make sense to give it as a continuous infusion (a continuous infusion will gradually accumulate and eventually cause overshoot hypotension).