This is equivalent to a delivered dose (ex actuator) of 21 micrograms of salmeterol and 220 micrograms of fluticasone propionate.The canister contains a white to off-white suspension.The canisters are fitted into white plastic actuators incorporating an atomising orifice and fitted with rubine red (25microgram/250 microgram) dust-caps.Sereflo is indicated in the regular treatment of patients with moderate to severe asthma where use of a combination product (long-acting β- patients not adequately controlled on a lower strength corticosteroid combination product- patients already adequately controlled on an inhaled corticosteroid in a mid or high strength and a long-acting βSereflo is indicated in adults 18 years of age and older only.Sereflo is not indicated for use in children, 12 years of age or younger, or adolescents, 13 to 17 years of age.Patients should be made aware that Sereflo must be used daily for optimum benefit, even when asymptomatic.Patients should be regularly reassessed by a doctor, so that the strength of Sereflo they are receiving remains optimal and is only changed on medical advice. The inhaler should be shaken immediately before releasing each puff. It contains Fluticasone, Propionate, and Salmeterol as active ingredients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.This medicine should be used with extreme caution in patients with latent or active infections since this medicine can suppress the immune system and worsen the patient's condition.

Do not use more than the prescribed dose. If the medicine is used, the infant should be monitored closely for any undesirable side effects.This medicine should be used with caution in patients with a known history of hypokalemia (low blood potassium levels) due to the increased risk of worsening of the patient's condition. Only limited data are available investigating the increase seen in drug delivery to the lungs with Sereflo when used with either the Volumatic spacer device or the AeroChamber Plus spacer device. What are the interactions of Seroflo 250 Inhaler ? Pack sizes:1, 2 (bundled package 2x1) or 3 (bundled package 3x1) canisters containing 120 doses.10 (bundled package 10x1) canisters containing 120 doses -hospital/pharmacy use onlyAny unused medicinal product or waste material should be disposed of in accordance with local requirements. It is unknown whether salmeterol and fluticasone propionate/metabolites are excreted in human milk.Studies have shown that salmeterol and fluticasone propionate, and their metabolites, are excreted into the milk of lactating rats.A risk to breastfed newborns/infants cannot be excluded.

Patients should be advised to have their inhaler to be used for relief in an acute asthma attack available at all times.Patients should not be initiated on Sereflo during an exacerbation, or if they have significantly worsening or acutely deteriorating asthma.Serious asthma-related adverse events and exacerbations may occur during treatment with Sereflo.

The adjusted odds ratio for MCMs diagnosed by 1 year was 1.1 (95%CI: 0.5 – 2.3) for FP exposed vs non-FP ICS exposed women with moderate asthma and 1.2 (95%CI: 0.7 – 2.0) for women with considerable to severe asthma. When suggestions are available use up and down arrows to review and ENTER to select. GOAL showed more patients treated with salmeterol and fluticasone propionate as a fixed-dose combination achieved asthma control than patients treated with inhaled corticosteroid (ICS) alone and this control was attained at a lower corticosteroid dose. Animal studies have shown reproductive toxicity after administration of βAdministration of salmeterol and fluticasone propionate to pregnant women should only be considered if the expected benefit to the mother is greater than any possible risk to the fetus.The lowest effective dose of fluticasone propionate needed to maintain adequate asthma control should be used in the treatment of pregnant women. Patients should immediately replace the mouthpiece cover in the correct orientation by firmly pushing and snapping the cover into position. Children may also experience anxiety, sleep disorders and behavioural changes, including hyperactivity and irritability.Reporting suspected adverse reactions after authorisation of the medicinal product is important. Homeopathic medicines are natural medicines and work by moderating our immune system which usually becomes overreactive in asthma. But I need to know...Continue with the seroflo. Protect it from moisture and light. The canister is pressurized and must be kept away from direct sunlight.

Patients should hold the inhaler upright between fingers and thumb with their thumb on the base, below the mouthpiece.5. Consideration should be given to increasing corticosteroid therapy.Once asthma symptoms are controlled, consideration may be given to gradually reducing the dose of Sereflo.
The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Keep away from eyes.

Each sales pack is available as canister containing 120 metered doses and a prescribing information.