Calcitonin has multiple pharma-cologic effects, but its primary effect is on bone, causing decreased bone resorption. A single dose of either two 4 mg tablets or two 4 mg capsules was administered under fed and fasting conditions in an open label, four period, randomized crossover study in 96 human volunteers, of whom 81 were eligible for the statistical analysis. Taking these drugs together could increase or prolong the therapeutic effects of silodosin; monitor patients for potential adverse effects. B Currently, nonformulary medications approved for therapeutic substation have to be discontinued by pharmacy and re-entered per pharmacy protocol A/R These recently approved therapeutic substitutions will be built into Cerner as a safer and more efficient process beginning 2/17/15. The pharmacodynamic interactions between silodosin and other alpha-blockers have not been determined; drug should not be used in combination with other alpha-blockers; Specific pharmacodynamic interaction study between this drug and antihypertensive agents not performed; patients in Phase 3 clinical studies taking concomitant antihypertensive medications did not …

Pharmacy will automatically dispense the approved therapeutic interchange. Zanaflex Capsules ® and Zanaflex ® tablets are bioequivalent to each other under fast conditions, but not under fed conditions. 341 0 obj <>stream h��Xkk�8�+�ز$zY�4e�v��e��l�)�ē�M�ะ��{�l9N�t����B B��}���XDrC�����p%��D� ��Q���劄N��[�&���8��X�#�װ 9�A��` !T�e �58��+!�=І�&�d80$P���D�$#J�b��3r�r�>~���;=����#�ݮ�)�$-�agg�$B#�wtHo�q�P� d��oT@��� ��K%c:�ʇqu��i^NG_+��>������yQ���y�� Please stand by, while we are checking your browser...Completing the CAPTCHA proves you are a human and gives you temporary access to the web property.If you are on a personal connection, like at home, you can run an anti-virus scan on your device to make sure it is not infected with malware.If you are at an office or shared network, you can ask the network administrator to run a scan across the network looking for misconfigured or infected devices. endstream endobj 299 0 obj <>/Metadata 8 0 R/PageLayout/OneColumn/Pages 296 0 R/StructTreeRoot 14 0 R/Type/Catalog>> endobj 300 0 obj <>/Font<>>>/Rotate 0/StructParents 0/Type/Page>> endobj 301 0 obj <>stream For further information, contact Janjri Desai, Manager of Clinical Effectiveness: . Another way to prevent getting this page in the future is to use Privacy Pass. P&T Committee approved therapeutic interchange of these products using the same dosage. 0

Silodosin (Rapaflo®) For patients with moderate kidney disease (CrCl 30 - 50ml/min), silodosin dose should be 4 mg a day; Silodosin should not be used in patients with severe kidney disease (CrCl < 30 ml/min) Tamsulosin (Flomax®) No dosage adjustment necessary in patients with kidney disease; Patients with CrCl < 10ml/min have not been studied h�bbd``b`:$[@D�`�b��X�@D�`Q�k-��bŃX�@���C �X$����?��{���ȸ$��H?�?��W Z�S Only therapeutic interchanges approved by the medical executive committee are allowed. In theory, drugs that inhibit CYP3A4, such as danazol, may cause significant increases in silodosin plasma concentrations.

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One of the most important treatment goal for …

Therapeutic Interchange is the practice of dispensing a therapeutically equivalent medication in place of the medication ordered. Alpha-1 Blockers, Urinary Drug Ordered Drug Dispensed Silodosin (Rapaflo) 8 mg daily … You may need to download version 2.0 now from the endstream endobj startxref

COMPARISON BETWEEN SILODOSIN AND TAMSULOSIN OF EARLY THERAPEUTIC EFFICACY IN PATIENTS WITH SEVERE BENIGN PROSTATIC HYPERPLASIA Hypothesis / aims of study The incidence of benign prostatic hyperplasia (BPH) is high in middle-aged and elderly men and their lower urinary tract symptoms are considered to be more severe with aging. From the June meeting of the SHC Pharmacy and Therapeutics Committee .

Formulary Additions: • Nivolumab (Opdivo®) is a fully humanized immunoglobulin G4 (IgG4) monoclonal antibody that selectively binds to the PD-1 receptor and blocks … %%EOF

Danazol: (Moderate) Silodosin is extensively metabolized by hepatic cytochrome P450 3A4. h�b```f``�a`a``�e`@ �+P��A��@��h)��Ǝ�H��aF�b!�H ?��v����0i������U``���rt�����3���j iF� ����+�e`d0 �12