The patient should be cautioned not to change the prescribed dosage regimen and not to add any additional antiparkinson medications, including other carbidopa and levodopa preparations, without first consulting the physician.Patients should be advised that sometimes a 'wearing-off' effect may occur at the end of the dosing interval. Iron salts (such as in multivitamin tablets) may also reduce the amount of levodopa available to the body. You may also report side effects at https://www.fda.gov/medwatch. It seems to help except during stressful times. They are supplied as follows:No. What I do is get up at 6 and medicate, then wait 2 hours before a 3 mile walk with Sushi, that way, meds are nearing peak effectiveness. 6723 — Sinemet 25-250 Tablets are light dapple-blue oval tablets that are plain on one side, with "654" and a score line on the other. Mostly it seems to be after a stressed evening rather than related to what I eat or do - meaning that I can have a sleepless night when I’m very tired but equally it can occur after a restful evening. Based on another study in forty patients with Parkinson's disease, there was a correlation between age of patients and the increase of AUC of levodopa following administration of levodopa and an inhibitor of peripheral dopa decarboxylase. Take two walks a day, go to gym but end up falling asleep and not much energy after noon.thanks pete. If you think there has been an overdose, call your poison control center or get medical care right away. They just tested me on many things ...I have sleep apnea, am being fitted for CPAP, and I have Asthma...I haven't started on Asthma meds yet because I have Ostioporosis and a lot of bone loss in my jaw bones....I have Low BP so I have Medorine to raise it, but I get light headed and have fallen several times...and with Osteoporosis, they fear if I fall I can beak a bone easily. They are supplied as follows:No. 3917 — Sinemet 25-250 Tablets are light dapple-blue, round, uncoated tablets, that are coded "654" on one side and plain on the other. When a greater proportion of carbidopa is required, one tablet of Sinemet 25-100 may be substituted for each tablet of Sinemet 10-100. Tablets of the two ratios may be given separately or combined as needed to provide the optimum dosage. This is linked to tiredness in many conditions and every now and then rears its ugly head in talk about Parkinson's. My best time is until 12 noon. The exercise help my energy level the afternoon and evening. I go to aerobic exercise class daily and physical therapy 2x/ week. But, alongside this, they have upped my walking needs to 7 miles a day to tryand avoid hip replacement. I go to aerobic exercise class daily and physical therapy 2x/ week. Kind regards. FDA Safety Alerts for all medications. A few days later I have as much energy as I can have (what with PD, etc.). I go to aerobic exercise class daily and physical therapy 2x/ week. Its empirical formula is CTablet content is expressed in terms of anhydrous carbidopa which has a molecular weight of 226.3.Levodopa, an aromatic amino acid, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 197.2. And yes you need to move, don't sleep to much it makes everything worse. For this reason, large doses of levodopa are required for adequate therapeutic effect, and these may often be accompanied by nausea and other adverse reactions, some of which are attributable to dopamine formed in extracerebral tissues.Since levodopa competes with certain amino acids for transport across the gut wall, the absorption of levodopa may be impaired in some patients on a high protein diet.Carbidopa inhibits decarboxylation of peripheral levodopa. Although the color appears to be clinically insignificant, garments may become discolored.The patient should be advised that a change in diet to foods that are high in protein may delay the absorption of levodopa and may reduce the amount taken up in the circulation. Sinemet 10-100 and 25-250 Tablets also contain FD&C Blue #2/Indigo Carmine AL. My best time is until 12 noon. Perhaps the backordered Sinemet situation may be the best thing to have happened to me. Any good suggestions for regaining energy. This apparently is an overlooked test for many. Sinemet … KADIE57Hi Kadie...and Grayland....I take 5 stalevo 200 per day ( 1 every 4 hrs.)