As a result, these agents can cause dry eye, which can usually be treated with lubricating drops, according to Dr. Chalam. Some side effects of telmisartan may occur that usually do not need medical attention. A review article he coauthored states that “the initial findings of tamoxifen retinopathy at an auspicious time in the evolution of BC [breast cancer] treatment have led to an overemphasis on this condition in the sense that vision symptoms (e.g., photopsia) due to other intraocular conditions may be too readily misattributed to tamoxifen retinopathy and/or downplayed.”According to Dr. Chalam, the ocular risks increase with long-term use of tamoxifen because the effects of the drug on the eye are cumulative over time. According to Dr. Eisner, 5-FU can sometimes result in epiphora, while methotrexate can lead to conjunctivitis and other inflammation of the ocular surface.Because chemotherapies are toxic to rapidly dividing cells (such as those in a tumor), they can also be harmful to other cells that divide and renew on a regular basis, including those in the corneal epithelium.
The breast cancer medication most commonly identified with ocular side effects is tamoxifen. “It’s fairly rare to find that a cataract is due to a medication, and I think that the jury is still out on whether tamoxifen may cause cataracts in some patients,” said Rick Fraunfelder, MD, MBA, professor of ophthalmology at Oregon Health & Science University and the Casey Eye Institute. Cerner Multum, Inc. "UK Summary of Product Characteristics." But there’s accumulating evidence that ocular conditions such as dry eye, retinopathy, and cataracts may be at least partly due to some breast cancer medications.Only a small percentage of breast cancer patients experience clinically evident ocular side effects from their medications. That’s not the case anymore with the usual dose of 20 mg or less.”Yet some ophthalmologists say that the question of whether tamoxifen increases risk of cataracts is still unresolved. Dr. Fraunfelder is also director of the National Registry of Drug-Induced Ocular Side Effects.But, according to Dr. Eisner, tamoxifen retinopathy is overemphasized. Dizziness 5. “It’s very rare for a patient to go completely blind, but many lines of visual acuity can be lost,” he said. O 03. Learn about side effects, warnings, dosage, and more. "Product Information. Drugs with direct action on the renin-angiotensin system can cause injury or death to the developing fetus. “If you start getting vision loss after taking tamoxifen, it can be progressive and may continue even if you stop the drug.”“Oncologists now have more choices, and patients experiencing ocular effects from tamoxifen can often be switched to raloxifene, although the use of raloxifene would be off label,” said Dr. Chalam.Chemotherapy drugs can also cause ocular side effects. And more researchers are becoming concerned that the drugs known as aromatase inhibitors, which now are often prescribed as adjuvant endocrine therapy, may also have adverse effects on the eye, including small retinal hemorrhages, increased incidence of floaters, and dry eye.“Tamoxifen has long been known to cause eye problems, including dryness, irritation, cataracts, and deposits in the retina, in the area of the macula, that result in macular edema,” said K. V. Chalam, MD, PhD, MBA, professor and chair of ophthalmology at the University of Florida College of Medicine in Jacksonville. “The chemicals irritate the eye, but the condition is temporary and goes away once the patient is done with chemotherapy,” Dr. Fraunfelder said, adding that there is no long-term damage. Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of telmisartan may occur that usually Check with your health care professional if any of the following side effects The most common adverse events reported in hypertension trials were back pain, sinusitis, and diarrhea. Telmisartan oral tablet is a prescription medication used to treat high blood pressure. “Certainly, the side effects we see with tamoxifen are much less profound than they used to be because of the lower doses now used.” Years ago, many breast cancer patients were prescribed doses of 150 mg or more, he noted. I have had no side effects and started on Micardis 40 mg by my endo and then he upped it to 80 mg to be safe.
Design: National Library of Medicine online bibliographic services were used to identify case reports and clinical studies of ocular adverse effects that occurred in patients receiving tamoxifen published through the fall of 1994. Dizziness 5. Inflammation Of The Tissue Lining The Sinuses 7. The most common adverse events reported in cardiovascular risk reduction trials were 1. Boehringer-Ingelheim, Ridgefield, CT. 2. Eisner pointed to the need for more studies of the effects of AIs, particularly longitudinal studies to better document and help clarify their ocular effects.“As many as 40 percent of women completely abandon their use of AIs before the prescribed time because they can’t tolerate the side effects. I am 56 years now and a type 1 diabetic since last 35 years. These side effects may go away during treatment as your body adjusts to the medicine.