Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. All rights reserved. Patients who may be required to have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. There was no evidence of carcinogenic potential when 0.025 mg/kg/day of Tretinoin was administered topically to mice (0.1 times the maximum human systemic dose, adjusted for total body surface area). Topical use may induce severe local erythema and peeling at the site of application. Tretinoin Gel, USP and Tretinoin Cream, USP are used for the topical treatment of acne vulgaris. It works partly by keeping skin pores clear. Although no definite pattern of teratogenicity and no causal association has been established from these cases, five of the reports describe the rare birth defect category holoprosencephaly (defects associated with incomplete midline development of the forebrain). Remember, when Tretinoin is To help you use the medication correctly, keep these simple instructions in mind.Tretinoin works deep inside your skin and this takes time. The safety and efficacy of the long-term use of this product in the treatment of other disorders have not been established.Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.If a reaction suggesting sensitivity or chemical irritation occurs, use of the medication should be discontinued. Let the face dry 20-30 minutes before applying Tretinoin. These doses are two and four times the maximum human systemic dose, when adjusted for total body surface area. In cases where it has been necessary to temporarily discontinue therapy or to reduce the frequency of application, therapy may be resumed or frequency of application increased when the patients become able to tolerate the treatment.Alterations of vehicle, drug concentration, or dose frequency should be closely monitored by careful observation of the clinical therapeutic response and skin tolerance.During the early weeks of therapy, an apparent exacerbation of inflammatory lesions may occur. Available for Android and iOS devices. The maximum systemic doses associated with the administered 0.017% and 0.035% formulations are 0.5 and 1.0 mg/kg/day, respectively. You cannot make Tretinoin work any faster by applying more than one dose each day, but an excess amount of Tretinoin may irritate your skin. Exposure to sunlight, including sunlamps, should be minimized during the use of Tretinoin, and patients with sunburn should be advised not to use the product until fully recovered because of heightened susceptibility to sunlight as a result of the use of Tretinoin. Gel: Excessive application results in “pilling” of the gel, which minimizes the likelihood of over application by the patient.Application may cause a transitory feeling of warmth or slight stinging. True contact allergy to topical Tretinoin is rarely encountered. All rights reserved. It works by lightening the skin, replacing older skin with newer skin, and slowing down the way the body removes skin cells that may have been harmed by the sun. These sunlight-induced tumors may appear more quickly and in greater number if the mouse is also topically treated with the active ingredient Tretinoin. Weather extremes, such as wind or cold, also may be irritating to patients under treatment with Tretinoin.Tretinoin preparations for acne treatment should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. Tretinoin Gel, USP and Tretinoin Cream, USP are used for the topical treatment of acne vulgaris.

Thirty human cases of temporally associated congenital malformations have been reported during two decades of clinical use of Tretinoin. Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition.Concomitant topical medication, medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices or lime should be used with caution because of possible interaction with Tretinoin. Because many drugs are excreted in human milk, caution should be exercised when Tretinoin is administered to a nursing woman.Safety and effectiveness in pediatric patients below the age of 12 have not been established.Safety and effectiveness in a geriatric population have not been established. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Tretinoin is used to treat acne or other skin diseases as determined by your doctor. Tretinoin works best when used within a skin care program that includes protecting the treated skin from the sun. THE LONG-TERM SAFETY AND EFFECTIVENESS OF THIS PRODUCT IN OTHER DISORDERS HAVE NOT BEEN EVALUATED. If these effects occur, the medication should either be discontinued until the integrity of the skin is restored, or the medication should be adjusted to a level the patient can tolerate. The significance of these spontaneous reports in terms of risk to the fetus is not known.Topical Tretinoin has been shown to be fetotoxic in rabbits when administered 0.5 mg/kg/day (8 times the maximum human systemic dose adjusted for total body surface area).

Remember, excessive irritation such as rubbing, too much washing, use of other medications not suggested by your physician, etc., may worsen your acne.To get the best results with Tretinoin therapy, it is necessary to use it properly.