Consider the possibility of multiple drug overdose.Wellbutrin XL (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. Do not give Wellbutrin XL to other people, even if they have the same symptoms you have. trailer Such symptoms should be reported to the patient’s prescriber or health professional, especially if they are severe, abrupt in onset, or were not part of the patient’s presenting symptoms. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.Chills, facial edema, edema, peripheral edema, musculoskeletal chest pain, photosensitivity, and malaise.Postural hypotension, hypertension, stroke, vasodilation, syncope, complete atrioventricular block, extrasystoles, myocardial infarction, phlebitis, and pulmonary embolism.Abnormal liver function, bruxism, gastric reflux, gingivitis, glossitis, increased salivation, jaundice, mouth ulcers, stomatitis, thirst, edema of tongue, colitis, esophagitis, gastrointestinal hemorrhage, gum hemorrhage, hepatitis, intestinal perforation, liver damage, pancreatitis, and stomach ulcer.Hyperglycemia, hypoglycemia, and syndrome of inappropriate antidiuretic hormone secretion.Ecchymosis, anemia, leukocytosis, leukopenia, lymphadenopathy, pancytopenia, and thrombocytopenia. The times to peak concentrations for the erythrohydrobupropion and threohydrobupropion metabolites are similar to that of hydroxybupropion. If you would like more information, talk with your healthcare provider. x�b```b``�c`e``�b�c@ >�Dž���Ω��{x��\^���"s�+��so2��~y��d�%�W�5��0نg�yͅK��'Mc6�y:[�U��4��qzs�E������Ws�s�m}(60�q1��r�ٞ�e��,���{V��D�iwc�!��/\>y E,.-����UBE�f׫�/U���#;��V�:�`"h� �F$�]�褆gR��k �M:�Z���J(��پ�d�u�I-z���U�ג��$��v�ߪl����!�k�\��/ԅ`�A;��/�!���9��ӽ PK�m�����N+!��vӪl�����|����:�=�` Wellbutrin XL is contraindicated in patients with a seizure disorder or conditions that increase the risk of seizure (e.g., severe head injury, arteriovenous malformation, CNS tumor or CNS infection, severe stroke, anorexia nervosa or bulimia, or abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs The incidence of seizure with Wellbutrin XL has not been formally evaluated in clinical trials. 0000012865 00000 n There has been a long-standing concern that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment.Pooled analyses of short-term placebo-controlled trials of antidepressant drugs (Selective Serotonin Reuptake Inhibitors [SSRIs] and others) show that these drugs increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (ages 18 to 24) with major depressive disorder (MDD) and other psychiatric disorders. The first trial demonstrated that the half-life of hydroxybupropion was significantly longer in 8 subjects with alcoholic liver disease than in 8 healthy volunteers (32±14 hours versus 21±5 hours, respectively). The second study included 2 fixed doses of bupropion (300 mg and 450 mg per day) and placebo. Wellbutrin XR 150 mg Retardtabletten bei Depressionen Mehr zu Inhaltsstoffe Anwendung Warnhinweise 0000003374 00000 n Use low initial doses of Wellbutrin XL and increase the dose gradually Bupropion, levodopa, and amantadine have dopamine agonist effects. 0000002704 00000 n False-positive test results may result even following discontinuation of bupropion therapy. Drug interactions can increase risk of hypertensive reactions. Pre-existing glaucoma is almost always open-angle glaucoma because angle-closure glaucoma, when diagnosed, can be treated definitively with iridectomy. Response during the open-label phase was defined as a CGI-Improvement Scale score of 1 (very much improved) or 2 (much improved) for each of the final 3 weeks. For more information, ask your healthcare provider or pharmacist.Call your doctor for medical advice about side effects. Concomitant use of MAOIs and bupropion is contraindicated because there is an increased risk of hypertensive reactions if bupropion is used concomitantly with MAOIs.